Switching strategies to mitigate HIV mutation

Title: Switching strategies to mitigate HIV mutation
Creator: Hernandez-Vargas, Esteban Abelardo; Colaneri, Patrizio; Middleton, Richard H.
Relation: IEEE Transactions on Control Systems Technology Vol. 22, Issue 4, p. 1623-1628
Publisher Link: http://dx.doi.org/10.1109/TCST.2013.2280920
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Resource Type: journal article
Date: 2014
Description: HIV mutates rapidly and may develop resistance to specific drug therapies. There is no general agreement on how to optimally schedule the available treatments for mitigating the effects of mutations. With a switched positive linear system, we examined different control strategies applied to a higher order nonlinear mutation model. Simulation results suggest that model predictive control could outperform the common clinical treatment recommendations. This brief is a step forward to develop further tools for helping the practitioners to find the optimal treatment schedule.
Subject: HIV; model predictive control (MPC); mutation; positive systems
Identifier: http://hdl.handle.net/1959.13/1295777
Identifier: uon:19118
Identifier: ISSN:1063-6536
Language: eng
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